I do feel that France would still be a hard enemy for the dukes of Brabant, it's more how they interact with France that'll make or break the dutch. I do think it'd get dicey a few times as France would want to get the romance speaking areas back tho.Something like that with France. The first half of the 16th century will be a bit of a wobble for them, but Charles IX's heir is gonna be harder on rebellious nobles.
As for the americas I really have no idea.
For the Americas I do think it'd be cool if colonisation deviates from otl. Dutch Brazil and new Amsterdam would be cool.